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Viral Infection Augments Nod1/2 Signaling to Potentiate Lethality Associated With Secondary Bacterial Infections

Secondary bacterial infection is a common sequela to viral infection and is associated with increased lethality and morbidity. However, the underlying mechanisms remain poorly understood. We show that the TLR3/MDA5 agonist poly I:C or viral infection dramatically augments signaling via the NLRs Nod1...

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Detalhes bibliográficos
Main Authors: Kim, Yun-Gi, Park, Jong-Hwan, Reimer, Thornik, Baker, Darren P., Kawai, Taro, Kumar, Himanshu, Akira, Shizuo, Wobus, Christiane, Núñez, Gabriel
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3125972/
https://ncbi.nlm.nih.gov/pubmed/21669398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2011.05.006
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