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Crohn’s Disease-Associated Nod2 Mutation Limits Production of Pro-Inflammatory Cytokines to Protect the Host from Enterococcus faecalis-Induced Lethality()
Nod2 mutations including L1007fsinsC are associated with the development of Crohn’s disease (CD). These CD-associated Nod2 mutations are common in healthy Caucasian populations, suggesting that they may confer some protective function, but experimental evidence is lacking. Using a mouse strain that...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3169738/ https://ncbi.nlm.nih.gov/pubmed/21849681 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001854 |
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