Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

5-hydroxymethylcytosine (5hmC) is a modified base present at low levels in diverse cell types in mammals(1–5). 5hmC is generated by the TET family of Fe(II) and 2-oxoglutarate-dependent enzymes through oxidation of 5-methylcytosine (5mC)(1,2,4–7). 5hmC and TET proteins have been implicated in stem c...

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Hauptverfasser: Pastor, William A., Pape, Utz J., Huang, Yun, Henderson, Hope R., Lister, Ryan, Ko, Myunggon, McLoughlin, Erin M., Brudno, Yevgeny, Mahapatra, Sahasransu, Kapranov, Philipp, Tahiliani, Mamta, Daley, George Q., Liu, X. Shirley, Ecker, Joseph R., Milos, Patrice M., Agarwal, Suneet, Rao, Anjana
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124347/
https://ncbi.nlm.nih.gov/pubmed/21552279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10102
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