Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

5-hydroxymethylcytosine (5hmC) is a modified base present at low levels in diverse cell types in mammals(1–5). 5hmC is generated by the TET family of Fe(II) and 2-oxoglutarate-dependent enzymes through oxidation of 5-methylcytosine (5mC)(1,2,4–7). 5hmC and TET proteins have been implicated in stem c...

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Detalhes bibliográficos
Main Authors: Pastor, William A., Pape, Utz J., Huang, Yun, Henderson, Hope R., Lister, Ryan, Ko, Myunggon, McLoughlin, Erin M., Brudno, Yevgeny, Mahapatra, Sahasransu, Kapranov, Philipp, Tahiliani, Mamta, Daley, George Q., Liu, X. Shirley, Ecker, Joseph R., Milos, Patrice M., Agarwal, Suneet, Rao, Anjana
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124347/
https://ncbi.nlm.nih.gov/pubmed/21552279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10102
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