Fusion Tyrosine Kinase NPM-ALK Deregulates MSH2 and Suppresses DNA Mismatch Repair Function: Novel Insights into a Potent Oncoprotein

The fusion tyrosine kinase NPM-ALK is central to the pathogenesis of ALK-positive anaplastic large cell lymphoma (ALK(+)ALCL). We recently identified that MSH2, a key DNA mismatch repair (MMR) protein integral to the suppression of tumorigenesis, is an NPM-ALK–interacting protein. In this study, we...

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Detalhes bibliográficos
Main Authors: Young, Leah C., Bone, Kathleen M., Wang, Peng, Wu, Fang, Adam, Benjamin A., Hegazy, Samar, Gelebart, Pascal, Holovati, Jelena, Li, Liang, Andrew, Susan E., Lai, Raymond
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2011
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123797/
https://ncbi.nlm.nih.gov/pubmed/21703420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.03.045
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