The Tyrosine 343 Residue of Nucleophosmin (NPM)-Anaplastic Lymphoma Kinase (ALK) Is Important for Its Interaction with SHP1, a Cytoplasmic Tyrosine Phosphatase with Tumor Suppressor Functions

The cytoplasmic tyrosine phosphatase SHP1 has been shown to inhibit the oncogenic fusion protein nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK), and loss of SHP1 contributes to NPM-ALK-mediated tumorigenesis. In this study, we aimed to further understand how SHP1 interacts and regulates NPM-AL...

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Detalhes bibliográficos
Main Authors: Hegazy, Samar A., Wang, Peng, Anand, Mona, Ingham, Robert J., Gelebart, Pascal, Lai, Raymond
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888392/
https://ncbi.nlm.nih.gov/pubmed/20424160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.121988
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