NPM-ALK: The Prototypic Member of a Family of Oncogenic Fusion Tyrosine Kinases

Anaplastic lymphoma kinase (ALK) was first identified in 1994 with the discovery that the gene encoding for this kinase was involved in the t(2;5)(p23;q35) chromosomal translocation observed in a subset of anaplastic large cell lymphoma (ALCL). The NPM-ALK fusion protein generated by this translocat...

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Detalhes bibliográficos
Main Authors: Pearson, Joel D., Lee, Jason K. H., Bacani, Julinor T. C., Lai, Raymond, Ingham, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Review Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407651/
https://ncbi.nlm.nih.gov/pubmed/22852078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/123253
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