NPM-ALK mediates phosphorylation of MSH2 at tyrosine 238, creating a functional deficiency in MSH2 and the loss of mismatch repair

The vast majority of anaplastic lymphoma kinase-positive anaplastic large cell lymphoma (ALK+ALCL) tumors express the characteristic oncogenic fusion protein NPM-ALK, which mediates tumorigenesis by exerting its constitutive tyrosine kinase activity on various substrates. We recently identified MSH2...

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Detalhes bibliográficos
Publicado no:Blood Cancer J
Main Authors: Bone, K M, Wang, P, Wu, F, Wu, C, Li, L, Bacani, J T, Andrew, S E, Lai, R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476014/
https://ncbi.nlm.nih.gov/pubmed/25978431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2015.35
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