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Selective O-phosphitilation with nucleoside phosphoramidite reagents.

In contrast to tetrazole, pyridine hydrochloride/imidazole converts nucleoside phosphoramidites to intermediates that show a high preference for phosphitilating hydroxyl groups relative to nucleoside amino groups. Use of this activating agent and incorporation of a pyridine hydrochloride/aniline was...

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Bibliographic Details
Main Authors: Gryaznov, S M, Letsinger, R L
Format: Artigo
Language:Inglês
Published: 1992
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC312301/
https://ncbi.nlm.nih.gov/pubmed/1579488
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