Efficacy of Caspofungin in Neutropenic and Corticosteroid-Immunosuppressed Murine Models of Invasive Pulmonary Mucormycosis

Caspofungin (CFG) was tested in neutropenic and corticosteroid-immunosuppressed mice challenged with a lethal sinopulmonary inoculum of Rhizopus oryzae. Compared to untreated controls, CFG administered at 1 mg/kg of body weight/day significantly improved survival (54% versus 19%; P = 0.003) and redu...

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Bibliografiske detaljer
Main Authors: Lewis, Russell E., Leventakos, Konstantinos, Liao, Guangling, Kontoyiannis, Dimitrios P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2011
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122398/
https://ncbi.nlm.nih.gov/pubmed/21537029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01812-10
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