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Mutagenesis Mapping of the Presenilin 1 Calcium Leak Conductance Pore
Missense mutations in presenilin 1 (PS1) and presenilin 2 (PS2) proteins are a major cause of familial Alzheimer disease. Presenilins are proteins with nine transmembrane (TM) domains that function as catalytic subunits of the γ-secretase complex responsible for the cleavage of the amyloid precursor...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3121381/ https://ncbi.nlm.nih.gov/pubmed/21531718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.243063 |
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