Mutagenesis Mapping of the Presenilin 1 Calcium Leak Conductance Pore

Missense mutations in presenilin 1 (PS1) and presenilin 2 (PS2) proteins are a major cause of familial Alzheimer disease. Presenilins are proteins with nine transmembrane (TM) domains that function as catalytic subunits of the γ-secretase complex responsible for the cleavage of the amyloid precursor...

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Bibliographic Details
Main Authors: Nelson, Omar, Supnet, Charlene, Tolia, Alexandra, Horré, Katrien, De Strooper, Bart, Bezprozvanny, Ilya
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121381/
https://ncbi.nlm.nih.gov/pubmed/21531718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.243063
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