A Chimeric HIV-1 Envelope Glycoprotein Trimer with an Embedded Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF) Domain Induces Enhanced Antibody and T Cell Responses

An effective HIV-1 vaccine should ideally induce strong humoral and cellular immune responses that provide sterilizing immunity over a prolonged period. Current HIV-1 vaccines have failed in inducing such immunity. The viral envelope glycoprotein complex (Env) can be targeted by neutralizing antibod...

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Detalhes bibliográficos
Main Authors: van Montfort, Thijs, Melchers, Mark, Isik, Gözde, Menis, Sergey, Huang, Po-Ssu, Matthews, Katie, Michael, Elizabeth, Berkhout, Ben, Schief, William R., Moore, John P., Sanders, Rogier W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121371/
https://ncbi.nlm.nih.gov/pubmed/21515681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.229625
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