Inhibitors of Histone Deacetylases: CORRELATION BETWEEN ISOFORM SPECIFICITY AND REACTIVATION OF HIV TYPE 1 (HIV-1) FROM LATENTLY INFECTED CELLS

Deacetylation of histone proteins at the HIV type 1 (HIV-1) long terminal repeat (LTR) by histone deactylases (HDACs) can promote transcriptional repression and virus latency. As such, HDAC inhibitors (HDACI) could be used to deplete reservoirs of persistent, quiescent HIV-1 proviral infection. Howe...

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Detalhes bibliográficos
Main Authors: Huber, Kelly, Doyon, Geneviève, Plaks, Joseph, Fyne, Elizabeth, Mellors, John W., Sluis-Cremer, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121366/
https://ncbi.nlm.nih.gov/pubmed/21531716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.180224
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