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Knockdown of High Mobility Group Box 1 in Tumor Cells Attenuates Their Ability to Induce Regulatory T Cells and Uncovers Naturally Acquired CD8 T Cell-dependent Antitumor Immunity

Although high mobility group box 1 (HMGB1) in tumor cells is involved in many aspects of tumor progression, its role in tumor immune suppression remains elusive. Host cell-derived interleukin-10 (IL-10) suppressed a naturally acquired CD8 T cell-dependent antitumor response. The suppressive activity...

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Bibliografske podrobnosti
Main Authors: Liu, Zuqiang, Falo, Louis D., You, Zhaoyang
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119781/
https://ncbi.nlm.nih.gov/pubmed/21642542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003378
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