Mitochondrial Phosphatase PTPMT1 is essential for cardiolipin biosynthesis

PTPMT1 was the first protein tyrosine phosphatase found localized to the mitochondria, but its biological function was unknown. Herein, we demonstrate that whole body deletion of Ptpmt1 in mice leads to embryonic lethality, suggesting an indispensable role for PTPMT1 during development. Ptpmt1-defic...

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Main Authors: Zhang, Ji, Guan, Ziqiang, Murphy, Anne N., Wiley, Sandra E., Perkins, Guy A., Worby, Carolyn A., Engel, James L., Heacock, Philip, Nguyen, Oanh Kim, Wang, Jonathan H., Raetz, Christian R.H., Dowhan, William, Dixon, Jack E.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119201/
https://ncbi.nlm.nih.gov/pubmed/21641550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.04.007
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