Switching Cdk2 On or Off with Small Molecules to Reveal Requirements in Human Cell Proliferation

Multiple cyclin-dependent kinases (CDKs) control eukaryotic cell division, but assigning specific functions to individual CDKs remains a challenge. During the mammalian cell cycle, Cdk2 forms active complexes before Cdk1, but lack of Cdk2 protein does not block cell-cycle progression. To detect requ...

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Main Authors: Merrick, Karl A., Wohlbold, Lara, Zhang, Chao, Allen, Jasmina J., Horiuchi, Dai, Huskey, Noelle E., Goga, Andrei, Shokat, Kevan M., Fisher, Robert P.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119039/
https://ncbi.nlm.nih.gov/pubmed/21658603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.03.031
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