Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways

A family of conserved serine/threonine kinases known as cyclin-dependent kinases (CDKs) drives orderly cell cycle progression in mammalian cells. Prior studies have suggested that CDK2 regulates S-phase entry and progression, and frequently shows increased activity in a wide spectrum of human tumors...

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Autors principals: Horiuchi, Dai, E. Huskey, Noelle, Kusdra, Leonard, Wohlbold, Lara, Merrick, Karl A., Zhang, Chao, Creasman, Katelyn J., Shokat, Kevan M., Fisher, Robert P., Goga, Andrei
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
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PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340028/
https://ncbi.nlm.nih.gov/pubmed/22474407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111317109
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