Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease

Alzheimer's disease (AD) is the most common form of dementia and associated with progressive deposition of amyloid β-peptides (Aβ) in the brain. Aβ derives by sequential proteolytic processing of the amyloid precursor protein by β- and γ-secretases. Rare mutations that lead to amino-acid substi...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Kumar, Sathish, Rezaei-Ghaleh, Nasrollah, Terwel, Dick, Thal, Dietmar R, Richard, Mélisande, Hoch, Michael, Mc Donald, Jessica M, Wüllner, Ullrich, Glebov, Konstantin, Heneka, Michael T, Walsh, Dominic M, Zweckstetter, Markus, Walter, Jochen
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2011
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117653/
https://ncbi.nlm.nih.gov/pubmed/21527912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.138
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares