Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease

Alzheimer's disease (AD) is the most common form of dementia and associated with progressive deposition of amyloid β-peptides (Aβ) in the brain. Aβ derives by sequential proteolytic processing of the amyloid precursor protein by β- and γ-secretases. Rare mutations that lead to amino-acid substi...

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Main Authors: Kumar, Sathish, Rezaei-Ghaleh, Nasrollah, Terwel, Dick, Thal, Dietmar R, Richard, Mélisande, Hoch, Michael, Mc Donald, Jessica M, Wüllner, Ullrich, Glebov, Konstantin, Heneka, Michael T, Walsh, Dominic M, Zweckstetter, Markus, Walter, Jochen
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117653/
https://ncbi.nlm.nih.gov/pubmed/21527912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.138
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