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Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression
We have attempted to determine whether loss of mtDNA and respiratory chain function result in apoptosis in vivo. Apoptosis was studied in embryos with homozygous disruption of the mitochondrial transcription factor A gene (Tfam) and tissue-specific Tfam knockout animals with severe respiratory chain...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The National Academy of Sciences
2001
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC31175/ https://ncbi.nlm.nih.gov/pubmed/11259653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.061038798 |
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