Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression

We have attempted to determine whether loss of mtDNA and respiratory chain function result in apoptosis in vivo. Apoptosis was studied in embryos with homozygous disruption of the mitochondrial transcription factor A gene (Tfam) and tissue-specific Tfam knockout animals with severe respiratory chain...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Wang, Jianming, Silva, José P., Gustafsson, Claes M., Rustin, Pierre, Larsson, Nils-Göran
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31175/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11259653/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.061038798
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