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Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression
We have attempted to determine whether loss of mtDNA and respiratory chain function result in apoptosis in vivo. Apoptosis was studied in embryos with homozygous disruption of the mitochondrial transcription factor A gene (Tfam) and tissue-specific Tfam knockout animals with severe respiratory chain...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC31175/ https://ncbi.nlm.nih.gov/pubmed/11259653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.061038798 |
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