Genetic modification of survival in tissue-specific knockout mice with mitochondrial cardiomyopathy

We recently described a mouse model that reproduces important pathophysiological features of mitochondrial DNA (mtDNA) mutation diseases. The gene for mouse mitochondrial transcription factor A, Tfam (also called mtTFA), a nucleus-encoded key regulator of mtDNA expression, was targeted with loxP sit...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Li, Hong, Wang, Jianming, Wilhelmsson, Hans, Hansson, Anna, Thorén, Peter, Duffy, John, Rustin, Pierre, Larsson, Nils-Göran
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16263/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10737799/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.7.3467
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