Perturbation of the Stability of Amyloid Fibrils through Alteration of Electrostatic Interactions

The self-assembly of proteins and peptides into polymeric amyloid fibrils is a process that has important implications ranging from the understanding of protein misfolding disorders to the discovery of novel nanobiomaterials. In this study, we probe the stability of fibrils prepared at pH 2.0 and co...

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Detalhes bibliográficos
Main Authors: Shammas, Sarah L., Knowles, Tuomas P.J., Baldwin, Andrew J., MacPhee, Cait E., Welland, Mark E., Dobson, Christopher M., Devlin, Glyn L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2011
Assuntos:
Protein
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117150/
https://ncbi.nlm.nih.gov/pubmed/21641324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.04.039
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