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Competition between Primary Nucleation and Autocatalysis in Amyloid Fibril Self-Assembly

Kinetic measurements of the self-assembly of proteins into amyloid fibrils are often used to make inferences about molecular mechanisms. In particular, the lag time—the quiescent period before aggregates are detected—is often found to scale with the protein concentration as a power law, whose expone...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Eden, Kym, Morris, Ryan, Gillam, Jay, MacPhee, Cait E., Allen, Rosalind J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317560/
https://ncbi.nlm.nih.gov/pubmed/25650930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.11.3465
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