Binding of the Molecular Chaperone αB-Crystallin to Aβ Amyloid Fibrils Inhibits Fibril Elongation

The molecular chaperone αB-crystallin is a small heat-shock protein that is upregulated in response to a multitude of stress stimuli, and is found colocalized with Aβ amyloid fibrils in the extracellular plaques that are characteristic of Alzheimer's disease. We investigated whether this archet...

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Hlavní autoři: Shammas, Sarah L., Waudby, Christopher A., Wang, Shuyu, Buell, Alexander K., Knowles, Tuomas P.J., Ecroyd, Heath, Welland, Mark E., Carver, John A., Dobson, Christopher M., Meehan, Sarah
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2011
Témata:
Protein
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3183811/
https://ncbi.nlm.nih.gov/pubmed/21961594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.07.056
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