Ketones and lactate increase cancer cell “stemness”, driving recurrence, metastasis and poor clinical outcome in breast cancer: Achieving personalized medicine via metabolo-genomics

Previously, we showed that high-energy metabolites (lactate and ketones) “fuel” tumor growth and experimental metastasis in an in vivo xenograft model, most likely by driving oxidative mitochondrial metabolism in breast cancer cells. To mechanistically understand how these metabolites affect tumor c...

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Bibliographische Detailangaben
Hauptverfasser: Martinez-Outschoorn, Ubaldo E, Prisco, Marco, Ertel, Adam, Tsirigos, Aristotelis, Lin, Zhao, Pavlides, Stephanos, Wang, Chengwang, Flomenberg, Neal, Knudsen, Erik S, Howell, Anthony, Pestell, Richard G, Sotgia, Federica, Lisanti, Michael P
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2011
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117136/
https://ncbi.nlm.nih.gov/pubmed/21512313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.8.15330
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