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Cis-Regulatory Elements and Epigenetic Changes Control Genomic Rearrangements of the IgH Locus

Immunoglobulin variable region exons are assembled from discontinuous variable (V), diversity (D), and joining (J) segments by the process of V(D)J recombination. V(D)J rearrangements of the immunoglobulin heavy chain (IgH) locus are tightly controlled in a tissue-specific, ordered and allele-specif...

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Detalles Bibliográficos
Main Authors: Perlot, Thomas, Alt, Frederick W.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115588/
https://ncbi.nlm.nih.gov/pubmed/19117530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0065-2776(08)00601-9
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