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Cis-Regulatory Elements and Epigenetic Changes Control Genomic Rearrangements of the IgH Locus

Immunoglobulin variable region exons are assembled from discontinuous variable (V), diversity (D), and joining (J) segments by the process of V(D)J recombination. V(D)J rearrangements of the immunoglobulin heavy chain (IgH) locus are tightly controlled in a tissue-specific, ordered and allele-specif...

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Detalhes bibliográficos
Main Authors: Perlot, Thomas, Alt, Frederick W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115588/
https://ncbi.nlm.nih.gov/pubmed/19117530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0065-2776(08)00601-9
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