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Neuroinflammation and α-Synuclein Dysfunction Potentiate Each Other, Driving Chronic Progression of Neurodegeneration in a Mouse Model of Parkinson’s Disease
BACKGROUND: Mechanisms whereby gene–environment interactions mediate chronic, progressive neurodegenerative processes in Parkinson’s disease (PD)—the second most common neurodegenerative disease—remain elusive. OBJECTIVE: We created a two-hit [neuroinflammation and mutant α-synuclein (α-syn) overexp...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Institute of Environmental Health Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3114815/ https://ncbi.nlm.nih.gov/pubmed/21245015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.1003013 |
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