TREM2 deficiency aggravates α-synuclein–induced neurodegeneration and neuroinflammation in Parkinson’s disease models

Variants in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) are known to increase the risk of developing Alzheimer disease and Parkinson’s disease (PD). However, the potential role of TREM2 effect on synucleinopathy has not been characterized. In this study, we investi...

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Udgivet i:FASEB J
Main Authors: Guo, Ying, Wei, Xinbing, Yan, Hua, Qin, Yue, Yan, Shaoqi, Liu, Jia, Zhao, Yong, Jiang, Fan, Lou, Haiyan
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6902667/
https://ncbi.nlm.nih.gov/pubmed/31370707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900992R
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