Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways

Ion cotransporters, such as the Na(+)/Cl(−) cotransporter (NCC), control renal salt re-absorption and are regulated by the WNK-signalling pathway, which is over-stimulated in patients suffering from Gordon's hypertension syndrome. Here, we study the regulation of the NKCC2 (SLC12A1) ion cotrans...

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Bibliografiske detaljer
Main Authors: Richardson, Ciaran, Sakamoto, Kei, de los Heros, Paola, Deak, Maria, Campbell, David G., Prescott, Alan R., Alessi, Dario R.
Format: Artigo
Sprog:Inglês
Udgivet: Company of Biologists 2011
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114804/
https://ncbi.nlm.nih.gov/pubmed/21321328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.077230
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