Diagnostic evaluation of a nanobody with picomolar affinity towards the protease RgpB from Porphyromonas gingivalis

Porphyromonas gingivalis is one of the major periodontitis-causing pathogens. P. gingivalis secretes a group of proteases, termed gingipains, and in this study we have utilized the RgpB gingipain as a biomarker for P. gingivalis. We constructed a naïve camel nanobody library and used phage display t...

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Detalhes bibliográficos
Main Authors: Skottrup, Peter Durand, Leonard, Paul, Kaczmarek, Jakub Zbigniew, Veillard, Florian, Enghild, Jan J., O’Kennedy, Richard, Sroka, Aneta, Clausen, Rasmus Prætorius, Potempa, Jan, Riise, Erik
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114108/
https://ncbi.nlm.nih.gov/pubmed/21569755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2011.04.015
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