Efficient Immunoglobulin Gene Disruption and Targeted Replacement in Rabbit Using Zinc Finger Nucleases

Rabbits are widely used in biomedical research, yet techniques for their precise genetic modification are lacking. We demonstrate that zinc finger nucleases (ZFNs) introduced into fertilized oocytes can inactivate a chosen gene by mutagenesis and also mediate precise homologous recombination with a...

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書誌詳細
主要な著者: Flisikowska, Tatiana, Thorey, Irmgard S., Offner, Sonja, Ros, Francesca, Lifke, Valeria, Zeitler, Bryan, Rottmann, Oswald, Vincent, Anna, Zhang, Lei, Jenkins, Shirin, Niersbach, Helmut, Kind, Alexander J., Gregory, Philip D., Schnieke, Angelika E., Platzer, Josef
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2011
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113902/
https://ncbi.nlm.nih.gov/pubmed/21695153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021045
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