Efficient Immunoglobulin Gene Disruption and Targeted Replacement in Rabbit Using Zinc Finger Nucleases

Rabbits are widely used in biomedical research, yet techniques for their precise genetic modification are lacking. We demonstrate that zinc finger nucleases (ZFNs) introduced into fertilized oocytes can inactivate a chosen gene by mutagenesis and also mediate precise homologous recombination with a...

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Detalhes bibliográficos
Main Authors: Flisikowska, Tatiana, Thorey, Irmgard S., Offner, Sonja, Ros, Francesca, Lifke, Valeria, Zeitler, Bryan, Rottmann, Oswald, Vincent, Anna, Zhang, Lei, Jenkins, Shirin, Niersbach, Helmut, Kind, Alexander J., Gregory, Philip D., Schnieke, Angelika E., Platzer, Josef
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113902/
https://ncbi.nlm.nih.gov/pubmed/21695153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021045
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