Efficient Immunoglobulin Gene Disruption and Targeted Replacement in Rabbit Using Zinc Finger Nucleases

Rabbits are widely used in biomedical research, yet techniques for their precise genetic modification are lacking. We demonstrate that zinc finger nucleases (ZFNs) introduced into fertilized oocytes can inactivate a chosen gene by mutagenesis and also mediate precise homologous recombination with a...

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Main Authors: Flisikowska, Tatiana, Thorey, Irmgard S., Offner, Sonja, Ros, Francesca, Lifke, Valeria, Zeitler, Bryan, Rottmann, Oswald, Vincent, Anna, Zhang, Lei, Jenkins, Shirin, Niersbach, Helmut, Kind, Alexander J., Gregory, Philip D., Schnieke, Angelika E., Platzer, Josef
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113902/
https://ncbi.nlm.nih.gov/pubmed/21695153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021045
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