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TGFβ-and bleomycin-induced extracellular matrix synthesis is mediated through Akt and mammalian target of rapamycin (mTOR)
A number of pro-fibrogenic stimuli, such as growth factors, cytokines and extracellular matrix (ECM) proteins, involve Akt and its downstream substrates in mediating their effects. We previously reported that absence of Akt1, which is the predominant isoform of the three gene Akt family in vascular...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3113646/ https://ncbi.nlm.nih.gov/pubmed/21302298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.22648 |
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