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Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins
Cell adhesion by classical cadherins is mediated by dimerization of their EC1 domains through the “swapping” of N-terminal β-strands. We use molecular simulations, measurements of binding affinities, and x-ray crystallography to provide a detailed picture of the structural and energetic factors that...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3113550/ https://ncbi.nlm.nih.gov/pubmed/21572446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2051 |
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