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Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins

Cell adhesion by classical cadherins is mediated by dimerization of their EC1 domains through the “swapping” of N-terminal β-strands. We use molecular simulations, measurements of binding affinities, and x-ray crystallography to provide a detailed picture of the structural and energetic factors that...

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Autori principali: Vendome, Jeremie, Posy, Shoshana, Jin, Xiangshu, Bahna, Fabiana, Ahlsen, Goran, Shapiro, Lawrence, Honig, Barry
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113550/
https://ncbi.nlm.nih.gov/pubmed/21572446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2051
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