Two-step adhesive binding by classical cadherins

Crystal structures of classical cadherins have revealed two dimeric configurations: in the first, N-terminal β-strands of EC1 domains “swap” between partner molecules. The second configuration (the “X-dimer”), also observed for T-cadherin, is mediated by residues near the EC1-2 calcium binding sites...

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Autori principali: Harrison, Oliver, Bahna, Fabiana, Katsamba, Phini, Jin, Xiangshu, Brasch, Julia, Vendome, Jeremie, Ahlsen, Goran, Carroll, Kilpatrick, Price, Stephen, Honig, Barry, Shapiro, Lawrence
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872554/
https://ncbi.nlm.nih.gov/pubmed/20190754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1784
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