Dynamic Properties of a Type II Cadherin Adhesive Domain: Implications for the Mechanism of Strand-Swapping of Classical Cadherins

Cadherin-mediated cell adhesion is achieved through dimerization of cadherin N-terminal extracellular (EC1) domains presented from apposed cells. The dimer state is formed by exchange of N-terminal β-strands and insertion of conserved tryptophan indole side chains from one monomer into hydrophobic a...

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Main Authors: Miloushev, Vesselin Z., Bahna, Fabiana, Ciatto, Carlo, Ahlsen, Goran, Honig, Barry, Shapiro, Lawrence, Palmer, Arthur G.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2561228/
https://ncbi.nlm.nih.gov/pubmed/18682221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.05.009
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