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Sequence and structural determinants of strand swapping in cadherin domains: Do all cadherins bind through the same adhesive interface?

Cadherins are cell surface adhesion proteins important for tissue development and integrity. Type I and type II, or “classical”, cadherins form adhesive dimers via an interface formed through the exchange, or “swapping”, of the N-terminal β-strands from their membrane-distal EC1 domains. Here we ask...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Posy, Shoshana, Shapiro, Lawrence, Honig, Barry
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2435303/
https://ncbi.nlm.nih.gov/pubmed/18395225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.02.063
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