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Computational method to reduce the search space for directed protein evolution
We introduce a computational method to optimize the in vitro evolution of proteins. Simulating evolution with a simple model that statistically describes the fitness landscape, we find that beneficial mutations tend to occur at amino acid positions that are tolerant to substitutions, in the limit of...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The National Academy of Sciences
2001
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC31129/ https://ncbi.nlm.nih.gov/pubmed/11274394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051614498 |
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