Computational method to reduce the search space for directed protein evolution
We introduce a computational method to optimize the in vitro evolution of proteins. Simulating evolution with a simple model that statistically describes the fitness landscape, we find that beneficial mutations tend to occur at amino acid positions that are tolerant to substitutions, in the limit of...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2001
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31129/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11274394/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.051614498 |
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