Computational method to reduce the search space for directed protein evolution
We introduce a computational method to optimize the in vitro evolution of proteins. Simulating evolution with a simple model that statistically describes the fitness landscape, we find that beneficial mutations tend to occur at amino acid positions that are tolerant to substitutions, in the limit of...
Na minha lista:
| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2001
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31129/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11274394/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.051614498 |
| Tags: |
Sem tags, seja o primeiro a adicionar uma tag!
|