Noncanonical TGFβ Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice

Transforming growth factor–β (TGFβ) signaling drives aneurysm progression in multiple disorders, including Marfan syndrome (MFS), and therapies that inhibit this signaling cascade are in clinical trials. TGFβ can stimulate multiple intracellular signaling pathways, but it is unclear which of these p...

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Detalhes bibliográficos
Main Authors: Holm, Tammy M., Habashi, Jennifer P., Doyle, Jefferson J., Bedja, Djahida, Chen, YiChun, van Erp, Christel, Lindsay, Mark E., Kim, David, Schoenhoff, Florian, Cohn, Ronald D., Loeys, Bart L., Thomas, Craig J., Patnaik, Samarjit, Marugan, Juan J., Judge, Daniel P., Dietz, Harry C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111087/
https://ncbi.nlm.nih.gov/pubmed/21493862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1192149
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