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Angiotensin II Blockade and Aortic-Root Dilation in Marfan’s Syndrome

BACKGROUND: Progressive enlargement of the aortic root, leading to dissection, is the main cause of premature death in patients with Marfan’s syndrome. Recent data from mouse models of Marfan’s syndrome suggest that aortic-root enlargement is caused by excessive signaling by transforming growth fact...

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Detalhes bibliográficos
Main Authors: Brooke, Benjamin S., Habashi, Jennifer P., Judge, Daniel P., Patel, Nishant, Loeys, Bart, Dietz, Harry C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692965/
https://ncbi.nlm.nih.gov/pubmed/18579813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa0706585
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