Angiotensin II Type 2 Receptor Signaling Attenuates Aortic Aneurysm in Mice Through ERK Antagonism

Angiotensin II (AngII) mediates progression of aortic aneurysm, but the relative contribution of its type 1 (AT1) and type 2 (AT2) receptors remains unknown. We show that loss of AT2 expression accelerates the aberrant growth and rupture of the aorta in a mouse model of Marfan syndrome (MFS). The se...

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Detalhes bibliográficos
Main Authors: Habashi, Jennifer P., Doyle, Jefferson J., Holm, Tammy M., Aziz, Hamza, Schoenhoff, Florian, Bedja, Djahida, Chen, YiChun, Modiri, Alexandra N., Judge, Daniel P., Dietz, Harry C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3097422/
https://ncbi.nlm.nih.gov/pubmed/21493863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1192152
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