TGF-β–dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome

Mitral valve prolapse (MVP) is a common human phenotype, yet little is known about the pathogenesis of this condition. MVP can occur in the context of genetic syndromes, including Marfan syndrome (MFS), an autosomal-dominant connective tissue disorder caused by mutations in fibrillin-1. Fibrillin-1...

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Detalhes bibliográficos
Main Authors: Ng, Connie M., Cheng, Alan, Myers, Loretha A., Martinez-Murillo, Francisco, Jie, Chunfa, Bedja, Djahida, Gabrielson, Kathleen L., Hausladen, Jennifer M.W., Mecham, Robert P., Judge, Daniel P., Dietz, Harry C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC529498/
https://ncbi.nlm.nih.gov/pubmed/15546004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200422715
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