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TGF-β–dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome

Mitral valve prolapse (MVP) is a common human phenotype, yet little is known about the pathogenesis of this condition. MVP can occur in the context of genetic syndromes, including Marfan syndrome (MFS), an autosomal-dominant connective tissue disorder caused by mutations in fibrillin-1. Fibrillin-1...

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Published in:J Clin Invest
Main Authors: Ng, Connie M., Cheng, Alan, Myers, Loretha A., Martinez-Murillo, Francisco, Jie, Chunfa, Bedja, Djahida, Gabrielson, Kathleen L., Hausladen, Jennifer M.W., Mecham, Robert P., Judge, Daniel P., Dietz, Harry C.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2004
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Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC529498/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15546004/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI22715
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