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Allostery in a disordered protein: Oxidative modifications to α-Synuclein act distally to regulate membrane binding
Both oxidative stress and aggregation of the protein α-synuclein (aS) have been implicated as key factors in the etiology of Parkinson’s disease. Specifically, oxidative modifications to aS disrupt its binding to lipid membranes, an interaction considered critical to its native function. Here we see...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3110780/ https://ncbi.nlm.nih.gov/pubmed/21491910 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2009554 |
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