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N-terminal acetylation is critical for forming α-helical oligomer of α-synuclein

The aggregation of the protein α-synuclein (AS) is critical to the pathogenesis of Parkinson's disease. Although generally described as an unstructured monomer, recent evidence suggests that the native form of AS may be an α-helical tetramer which resists aggregation. Here, we show that N-termi...

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Hlavní autoři: Trexler, Adam J, Rhoades, Elizabeth
Médium: Artigo
Jazyk:Inglês
Vydáno: Wiley Subscription Services, Inc., A Wiley Company 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403458/
https://ncbi.nlm.nih.gov/pubmed/22407793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2056
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