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N-terminal acetylation is critical for forming α-helical oligomer of α-synuclein
The aggregation of the protein α-synuclein (AS) is critical to the pathogenesis of Parkinson's disease. Although generally described as an unstructured monomer, recent evidence suggests that the native form of AS may be an α-helical tetramer which resists aggregation. Here, we show that N-termi...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Wiley Subscription Services, Inc., A Wiley Company
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3403458/ https://ncbi.nlm.nih.gov/pubmed/22407793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2056 |
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