Establishment of a Chemical Synthetic Lethality Screen in Cultured Human Cells

The synthetic lethality screen is a powerful genetic method for unraveling functional interactions between proteins in yeast. Here we demonstrate the feasibility of a chemical synthetic lethality screen in cultured human cells, based in part on the concept of the yeast method. The technology employs...

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Main Authors: Simons, Arnold, Dafni, Naomi, Dotan, Iris, Oron, Yoram, Canaani, Dan
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2001
Teme:
Methods
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC311022/
https://ncbi.nlm.nih.gov/pubmed/11157789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.154201
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