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Genetic synthetic lethality screen at the single gene level in cultured human cells

Recently, we demonstrated the feasibility of a chemical synthetic lethality screen in cultured human cells. We now demonstrate the principles for a genetic synthetic lethality screen. The technology employs both an immortalized human cell line deficient in the gene of interest, which is complemented...

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Detalhes bibliográficos
Main Authors: Simons, Arnold H., Dafni, Naomi, Dotan, Iris, Oron, Yoram, Canaani, Dan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC60228/
https://ncbi.nlm.nih.gov/pubmed/11600719
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